Resveratrol
Also known as: trans-resveratrol
Resveratrol is a polyphenol found in grapes and red wine, taken for cardiovascular and longevity interest, with evidence that's promising but still mixed in humans.
What it is
A natural stilbene polyphenol (trans-3,4',5-trihydroxystilbene). It activates SIRT1 and antioxidant pathways and has anti-inflammatory and endothelial effects in studies, though human results are inconsistent partly due to individual differences in gut metabolism.1
Commonly used for
Cardiovascular: trials report improved flow-mediated dilation (blood vessel function) and reduced inflammatory markers (CRP, TNF-α) in at-risk patients; a meta-analysis suggested ≥150 mg/day may lower systolic blood pressure — though some meta-analyses found no clear cardiovascular benefit.12
Metabolic: consistently reduces inflammatory markers and improves aspects of dysregulated metabolism.3
Typical dosing
Trials span a wide range; resveratrol is generally well tolerated up to ~1 g/day. Cardiovascular studies have used doses from ~8 mg (grape-extract) up to 150 mg+/day.3
Route of administration
Oral, as capsules or tablets, typically as trans-resveratrol.
Storage & handling
Store at room temperature, away from heat, light, and moisture; resveratrol is light-sensitive.
Common considerations
May inhibit CYP3A4/CYP2C9 liver enzymes — caution with anticoagulants, NSAIDs, and other medications cleared by these pathways. Evidence in humans remains inconclusive overall.
References
- 1. Linus Pauling Institute, Oregon State University — Resveratrol (Micronutrient Information Center) Fact sheet
- 2. Frontiers in Pharmacology — Resveratrol and vascular health: evidence from clinical studies and mechanisms of action Review
- 3. Resveratrol for the Management of Human Health: A Systematic Review of Resveratrol Clinical Trials (PMC) Systematic review
The information on this page is provided for general educational purposes only. It is not medical advice and is not a substitute for consultation with a qualified healthcare provider. Individual needs, contraindications, and responses to supplementation vary, and decisions about starting, stopping, or modifying any supplement or medication should be made in consultation with a physician, pharmacist, or other appropriate professional. References are provided to authoritative sources; STACK Tracker does not endorse any specific product or brand.